Since the HTFC Screening System, very small samples, sample and reagent requirements are reduced by 50 to 90 % , resulting in significant cost savings what. The heightened sensitivity and multicolor capabilities of the flow cytometer detection system also enable additional applications including antibody screening, cytotoxicity studies and biomarker analysis. – ‘We are grateful that many of our first clients, who have been using earlier versions of our HyperCyt system with large pharmaceutical companies, biotechnology companies and leading academic research institutions led feedback on many of the new powerful and user – friendly features in the HTFC Screening. System, ‘said Dunlay.. Using the HTFC Screening System, researchers can analyze multiparameter cell populations or multiplexed bead suspensions in 96 – and 384 – well microplates with speeds up to 40 holes per minute, collecting data on thousands of cells per second.
The HTFC Screening System represents a significant breakthrough in high content screening, the the types of cells and multiplexed assays that can be used for testing compounds in drug discovery, said Terry Dunlay, IntelliCyt President and CEO. By coupling our high-throughput sampler with the large dynamic range and multiplexing capability of flow cytometry-based detectors, the HTFC Screening System scientists powerful advantages over other currently available technologies. .. Developed permit large scale large scale, high throughput, high content screening takes IntelliCyt new HTFC Screening System a revolutionary approach to cell-based screening by integrating proprietary HyperCy technology and flow cytometry – the most sensitive technology for measuring fluorescent markers cells in suspension – with HyperCytPRO, IntelliCyt advanced server-based computer science platform.– The results have been ‘the exact opposite of what I had expected,’Dr. Chandra Sreeganga, wrote professor at the Center for Basic Neuroscience and lead author on the studies. ‘The recovered animals to one year or longer a year or more. ‘.. But mouse its been grown run through to produce an excess of man alpha-synuclein a slow progressing neurodegeneration is similar PD. To researchers bred mice lacking CSPs in mice with an excessive man synuclein in the brain, in anticipation to see faster descent in which PD -like symptoms in the offspring.
The researchers suspect that the formation of of Lewy bodies alpha-synuclein is from transport into cells, thus remove its protective effect.. Testing these hypothesis of would involve are looking for mutations in the genes of CSP -alpha or alpha-synuclein patients with neurodegenerative diseases. Trying to understand said membranes in a dying the brain be very difficult, Dr. Gill of Centre for Research on Brain Cell Communication and C. Vincent Prothro Center for Basic Neuroscience conducts runs. The work was supported by the NIH, the American PD Disease Association and the Spanish Ministry of Education.
In humans, clump of alpha-synuclein, is called Lewy bodies in the brain cells of patient with Parkinson, Alzheimer and other degenerative diseases been found.