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The large team of scientists that study included Professors Paul Schimmel and Xiang – Lei Yang, scientific co-founder of aTyr Pharma and Leslie Nangle, Director of Research at aTyr Pharma, and Albena Albena Jordanova the University of Antwerp. Other researchers contributing to this work. From the University of Antwerp, Universiteit Leuven , and Florida Atlantic University Professor Paul Schimmel of The Scripps Research Institute, describes the importance of the work. ‘Charcot-Marie-Tooth is one of the most common inherited neurological disorders, with typical symptoms usually emerging in early adulthood, including loss of muscle mass, pain and sensitivity, in humans. And difficulty walking. Sequencing of the human genome showed that some CMT patients have mutations in a gene, which tyrosyl-tRNA synthetase. While tRNA synthetases play a fundamental role in protein synthesis in all forms of life, these dominant mutations in CMT patients, the disease did not seem to manifest by disturbances of protein synthesis activities. If the human mutation are introduced into the Drosophila genome, the flies develop neurological defects CMT correspond in humans. While we are still trying to understand how mutations in the tRNA synthetase gene disrupt the neurological system of a complex organism, this study showed that there is neurological functions encoded in this gene. ‘ – According to Jeff Watkins, CEO of aTyr Pharma: ‘In recent years, Professor Schimmel a whole new field a whole new area of biology: novel signaling functions for naturally occurring proteins from ancient proteins such as tRNA synthetases resected This work. Drosophila shows a surprising pathogenic tRNA synthetases role for not to the well-studied protein synthesis activities of these enzymes is related. Instead , in humans and this fruit model encoded the tyrosyl-tRNA synthetase gene in a different function of the involved complex neurobiology of an organism. These new activities are seen for other members of the tRNA synthetases family as well, and aTyr Pharma portfolio benefited from this new area of biology by, these naturally occurring resectins with novel signaling activities to treat a variety of diseases, such as inflammation automimmune, hematopoietic and metabolic disorders.
Recently juvenile violence, its social status climbers.New research deepen of social relations between males and females youths, relational of violence and psycho-social matching factors such as loneliness, self-esteem and contentment with life The results indicate that young people who will be better appreciated and groups group wants to be the most probable to is violent.