As explained in Staying Healthy With Diet by Dr. Elson Haas, M.D.: For a long period of background, the niacin insufficiency disease, pellagra, was an extremely serious and fatal problem. Characterized as the condition of the three Ds, pellagra causes its victims to experience dermatitis, diarrhea, and dementia. The 4th D was death. As referred to previously, the traditional B3 deficiency occurs primarily in cultures whose diet programs rely greatly on corn and where in fact the corn is not prepared in a way that releases its niacin. One of the first indications of pellagra, or niacin deficiency, may be the skin’s sensitivity to light, and the skin becomes rough, thick, and dried out . The skin after that becomes darkly pigmented, especially in areas of the physical body prone to be hot and sweaty or those subjected to sun.Fish is rich in multiple beneficial nutrition, including omega-3 essential fatty acids, high-quality proteins, vitamins and minerals, which were connected with decreased threat of depression from our research, Li said. The researchers pointed out that it is possible that the omega-3 fatty acids in fish may change the structure of human brain membranes, or these acids may alter the true way certain neurotransmitters work. Neurotransmitters are the brain’s chemical messengers, sending information from brain cell to brain cell. Some neurotransmitters, such as for example serotonin and dopamine, are usually involved in depression, the researchers said. The report was published Sept. 10 on-line in the Journal of Epidemiology & Community Health.