Ivory Coastline and Guinea-Bissau also closed borders to safeguard against Ebola Two various other countries surrounding the Ebola ‘hot zone,’ Ivory Coastline and Guinea-Bissau, have taken similar proactive actions to protect against Ebola. Both of these national countries talk about borders with at least probably the most affected countries, which include Sierra Leone, Liberia and Guinea, so it is only natural for them to pay close attention to who’s crossing their borders. Air travel is restricted in a variety of additional African countries also, including in South Africa, Zambia and Kenya, none of which can be found close to the hot zone.The frequencies of CRLF2 rearrangement and concomitant JAK1 or JAK2 mutation in the entire cohort are consistent with previous reviews,11,35 with the highest frequency observed in adolescent ALL . Previous reports have shown that the JAK2 inhibitor ruxolitinib is normally active in types of ALL with CRLF2 rearrangement, which implies that JAK inhibition might be used in the treating these high-risk patients.36,37 The next major subgroup of Ph-like ALL is seen as a fusions involving ABL-class kinase genes. Multiple ABL1 and PDGFRB fusions and brand-new targets of rearrangement had been identified, including ABL2 and CSF1R , which are recognized to respond to the ABL1 inhibitor imatinib.11 A striking finding was the high frequency of rearrangements activating JAK2, in young adults particularly.