Also, the chance of awareness may be increased with additional risk factors and coexisting conditions incrementally. Finally, notwithstanding major developments in our understanding of anesthesia and consciousness,33,34 until we clarify completely the mechanisms and measurement of anesthetic-induced unconsciousness and amnesia, some patients are likely to possess this complication still. Despite its wide scope, the BAG-RECALL trial has a true number of limitations.What’s more, brain autopsies showed that Alzheimer’s patients who’d been heavier in middle age generally had more mind tangles – – twisted strands of protein that build up in the brains of people with the disease. It’s not crystal clear, however, whether those human brain abnormalities will be the reason for the sooner Alzheimer’s, Thambisetty said. Plus, he noted, there were some factors that his team cannot account for – – such as the quality of people’s diet plans. That’s important because analysis has suggested, for example, that a Mediterranean diet – – rich in vegetables, fruit, and good fats from essential olive oil and fish – – can help stave off Alzheimer’s, according to the Institute on Aging.