An early subepidermal cleft was noticeable .. A jet-dark lesion with ragged borders A man presents with urticarial patches in his trunk and limbs. What are these lesions and how should they be treated? Over a three-month period, a 57-year-old man developed pruritic urticarial patches over his trunk and limbs . The individual lesions would persist for times to weeks and coalesced to create plaques often. Skin biopsy showed an epidermis that was included in a loose stratum corneum. There was focal separation of keratinocytes , and the upper dermis showed a perivascular interstitial infiltrate of lymphocytes as well as numerous eosinophils.You should even go for medications which can help you in avoiding heavy bleeding. Nervous system Nervous system unwanted effects of misoprostol can also prove to be quite harmful for you personally and headache may be the most common side-effect which is connected with this medication. Some of the other side effects include neuropathy and dizziness. Delusions and lethargy have been described with concomitant usage of misoprostol largely. So, this was all that you should know about misoprostol unwanted effects in detail.