31, 2011, to enable the FDA to boost its collection and distribution of drug shortage details. The steps the Culture has bought out the past year experienced impact. Following the introduction of bills in the House and Senate this past year mandating early notification by producers of drugs an issue, ASH was the first medical society to call on Congress to conduct hearings and provides made recommendations on methods to prevent and mitigate drug shortages that are being incorporated into legislative and regulatory proposals. ASH will continue to monitor all hematologic medication shortages closely and can continue to use policy makers to protect the fitness of Americans.. $498 million to reinforce response to bioterror episodes, infectious diseases, and natural disasters HHS Secretary Tommy G.However, these mutations often occur together in the same patient, and several are associated with set up prognostic markers. To determine the relative contribution of mutation status to overall survival, we generated a multivariable Cox model, using a variable-selection treatment incorporating age stepwise, sex, IPSS classification, and mutation position for the 13 the majority of mutated genes identified in this study frequently. As expected, age and IPSS risk group were strongly connected with overall survival . But mutations in TP53, EZH2, ETV6, RUNX1, and ASXL1 also emerged as independent predictors of survival. Mutation of NRAS, previously reported as a marker of poor prognosis, did not impact survival in this model, most likely owing to strong associations between oncogenic NRAS components and mutations of the IPSS.