12 Possible Lupus Signs or symptoms At the onset of lupus, the symptoms have become general commonly, making diagnosis of the condition difficult sometimes. The most typical initial complaints are exhaustion, fever, and muscle tissue and joint pain. That is called a ‘flu-like syndrome.’ Fatigue is the most common and bothersome complaint. It is also often the only symptom that remains after treatment of acute flares. A flare in lupus is an acute upsurge in symptoms.Fever during lupus flares is usually low-grade, exceeding 102 F rarely.But some health policy experts be concerned that provisions of regulations designed to improve health care quality could exacerbate gaps in access and outcomes by penalizing the hospitals that minority and poor individuals rely on the most . This article was reprinted from kaiserhealthnews.org with permission from the Henry J. Kaiser Family Foundation. Kaiser Health Information, an unbiased news service editorially, is a scheduled system of the Kaiser Family Foundation, a nonpartisan health care policy research corporation unaffiliated with Kaiser Permanente..