With the decrease in blood flow rate, tissues stop swelling. That’s why you can actually reduce the pain through the use of ice on the affected region. To use ice on the joint you should 1st wrap the ice in a towel and put on the particular joint for 15 minutes. Keep on with this process every hour for the majority of the first time. On the second day, you can do the same thing for approximately 4 to 5 times a full day. Hydrotherapy Warm water decreases the pressure on joints and muscles, so a warm bath can come in handy to lessen joints like hip and knee. You can immerse the particular affected part and massage it to stimulate the blood circulation.We screened these 152 patients for mutations in CFH, MCP, CFI, and THBD. Sufferers with THBD mutations were screened for CFB and C3 mutations also.29 The analysis was approved by the bioethics committee of the Province of Bergamo, Italy. Individuals or their legal guardians provided written informed consent. Study Assessments The sequencing methods and in vitro assays which were used to gauge the ramifications of purified thrombomodulin or cell-surface thrombomodulin on the generation and deposition of C3b proteolytic fragments and on thrombin-mediated activation of TAFI are defined in the Methods section in the Supplementary Appendix.